In Manhattan, cockroaches are spreading the deadly “Strickler’s disease” that is claiming hundreds of the city’s children. Dr. Peter Mann, Deputy Director of the CDC, recruits entomologist Dr. Susan Tyler, who uses genetic engineering to create what she calls the Judas breed, a hybrid between a mantis and a termite that releases an enzyme which accelerates the roaches’ metabolism, thus causing them to starve to death faster than they can nourish themselves. The disease is successfully eradicated, and Peter and Susan later marry.

Three years later, a priest is chased and dragged underground by a strange assailant. The only witness is Chuy, the autistic ward of an immigrant subway shoe shiner named Manny. Two kids later sell a “weird bug” from the subway to Susan, which she performs tests on, and realizes is similar to the Judas breed. Initially, she believes that this is impossible, since the specimens she released were all-female and designed with a lifespan of only a few months, ensuring that the breed would die off after a single generation. She later consults with her mentor, Dr. Gates, who autopsies a larger specimen found in the city’s sewage treatment plants, and finds that its organs are fully formed, meaning the Judas breed is not only alive, but has developed into a viable species, with a sizable colony underneath the city.

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